Akira Ainai Selected Research

Secretory Immunoglobulin A (SIgA)

1/2021	An influenza HA stalk reactive polymeric IgA antibody exhibits anti-viral function regulated by binary interaction between HA and the antibody.
1/2019	CpG ODN G9.1 as a novel nasal ODN adjuvant elicits complete protection from influenza virus infection without causing inflammatory immune responses.
1/2019	IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody.
7/2017	Intranasal Administration of Whole Inactivated Influenza Virus Vaccine as a Promising Influenza Vaccine Candidate.
1/2017	The road to a more effective influenza vaccine: Up to date studies and future prospects.
6/2015	Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus.
2/2009	Development of mucosal adjuvants for intranasal vaccine for H5N1 influenza viruses.

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Akira Ainai Research Topics

Disease

25	Infections 01/2022 - 02/2009
20	Human Influenza (Influenza) 01/2021 - 02/2009
6	Virus Diseases (Viral Diseases) 01/2021 - 01/2011
5	Pneumonia (Pneumonitis) 10/2021 - 08/2013
3	Asthma (Bronchial Asthma) 01/2017 - 08/2013
3	Communicable Diseases (Infectious Diseases) 07/2014 - 01/2006
2	COVID-19 01/2022 - 01/2021
2	Disseminated Intravascular Coagulation 10/2021 - 01/2018
2	Type 2 Diabetes Mellitus (MODY) 01/2014 - 01/2011
1	Breakthrough Infections 01/2022
1	Whooping Cough (Pertussis) 01/2022
1	Disease Progression 10/2021
1	Septic Shock (Toxic Shock Syndrome) 09/2020
1	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 05/2020
1	Thrombosis (Thrombus) 01/2018
1	Bites and Stings (Sting) 12/2017
1	Inflammation (Inflammations) 01/2017
1	Atherosclerosis 01/2014
1	Anemia 01/2011
1	Periodontal Diseases (Periodontal Disease) 01/2011
1	Diabetes Mellitus 01/2011
1	Chronic Renal Insufficiency 01/2011
1	Viral Pneumonia 04/2010
1	Neoplasms (Cancer) 01/2006

Drug/Important Bio-Agent (IBA)

19	VaccinesIBA 01/2022 - 02/2009
13	Immunoglobulin A (IgA)IBA 01/2021 - 10/2010
10	AntibodiesIBA 01/2021 - 01/2006
7	Secretory Immunoglobulin A (SIgA)IBA 01/2021 - 02/2009
7	Hemagglutinins (Hemagglutinin)IBA 01/2021 - 01/2011
7	Immunoglobulin G (IgG)IBA 01/2019 - 10/2010
6	Influenza Vaccines (Influenza Vaccine)FDA Link 04/2020 - 08/2012
4	CytokinesIBA 10/2021 - 08/2013
3	Neutralizing AntibodiesIBA 01/2022 - 01/2018
3	Biomarkers (Surrogate Marker)IBA 10/2021 - 01/2011
3	Inactivated VaccinesIBA 04/2020 - 01/2011
2	Messenger RNA (mRNA)IBA 01/2022 - 01/2010
2	ThrombomodulinIBA 10/2021 - 01/2018
2	Dacarbazine (DIC)FDA LinkGeneric 10/2021 - 01/2018
2	Monoclonal AntibodiesIBA 09/2020 - 01/2011
2	Double-Stranded RNA (RNA, Double Stranded)IBA 09/2020 - 10/2010
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 04/2010
2	AntigensIBA 01/2019 - 06/2015
2	Antiviral Agents (Antivirals)IBA 01/2019 - 01/2018
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 08/2013
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	ChemokinesIBA 10/2021
1	polymeric IgAIBA 01/2021
1	Glycoproteins (Glycoprotein)IBA 01/2021
1	Methacholine Chloride (Methacholine)FDA Link 01/2021
1	Clostridium perfringens theta-toxinIBA 09/2020
1	streptolysin OIBA 09/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 09/2020
1	Poly I-CIBA 09/2020
1	Poly CIBA 09/2020
1	Poly IIBA 09/2020
1	CPG-oligonucleotideIBA 01/2019
1	OligodeoxyribonucleotidesIBA 01/2019
1	EpitopesIBA 01/2019
1	GoldIBA 05/2018
1	Therapeutic UsesIBA 01/2018
1	Immunoglobulin M (IgM)IBA 01/2018
1	Immunoglobulin E (IgE)IBA 01/2018
1	Immunoglobulin D (IgD)IBA 01/2018
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 12/2017
1	Immunoglobulins (Immunoglobulin)IBA 12/2017
1	InterferonsIBA 12/2017
1	Vaccine AdjuvantsIBA 12/2017
1	SolutionsIBA 06/2015
1	HDL CholesterolIBA 01/2014
1	CathelicidinsIBA 01/2014
1	InterleukinsIBA 08/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2013
1	Transforming Growth Factor beta (TGF-beta)IBA 08/2013
1	Interleukin-10 (Interleukin 10)IBA 08/2013
1	Interleukin-13IBA 08/2013
1	AlbuminsIBA 01/2011
1	25-hydroxyvitamin DIBA 01/2011
1	Cholinesterases (Cholinesterase)IBA 01/2011
1	Vitamin D FDA LinkGeneric 01/2011
1	Hemoglobins (Hemoglobin)IBA 01/2011
1	CreatinineIBA 01/2011
1	Combined VaccinesIBA 10/2010
1	RNA (Ribonucleic Acid)IBA 01/2010
1	Toll-Like Receptor 3IBA 10/2009
1	poly(I).poly(c12,U) (ampligen)IBA 10/2009

Therapy/Procedure

4	Intranasal Administration 11/2015 - 01/2010
2	Injections 07/2017 - 01/2017
1	Mechanical Ventilators (Ventilator) 01/2021
1	Personal Protective Equipment 01/2021
1	Isogeneic Transplantation 05/2020
1	Therapeutics 01/2018
1	Intramuscular Injections 07/2017